TSU searches for a way to help the immune system accept implants

In a current project, TSU scientists and international colleagues are searching for ways to improve the survival rate of bone implants. The staff studies features of the immune system’s response to a foreign body, to minimize biological processes related to its rejection. Currently, biopolymers, composites based on them, and nanoceramics created by TSU scientists are being tested at universities in Germany and Greece.

- One of the main problems arising from the implantation of foreign bodies in the body is  inflammation, which can lead to implant failure, - said Julia Kzhyshkovska, head of the TSU Laboratory for Translational Cell and Molecular Biomedicine and professor at the Heidelberg University. - In order to reduce the risk of complications to a minimum, you need to figure out the response of immune system cells to the material and try to regulate these processes.

TSU scientists perform checks of the biocompatibility at the Institute of Transfusion Medicine and Immunology (Medical Faculty Mannheim) of Heidelberg University. For nearly two years, researchers at TSU Laboratory for Translational Cell and Molecular Biomedicine conducted experiments in which they studied the mechanisms of the interaction of biomaterials with the cell environment.

Chemists and biologists tested the reaction of the immune defense system to the components of the composite and the impact of physical and chemical properties of the material (composition, roughness and porosity, and others) on the immune response. The data helped to choose the optimal composition of composites to improve the immunotolerance of biomaterials.

The next target for testing biocompatibility will be nanoceramics created by the TSU Faculty of Physics and Engineering and the Institute of Strength Physics and Materials Science SB RAS for the manufacture of intervertebral cages and small joints of the extremities. Currently, the University of Crete (Greece) has been researching the properties of the material.